| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | Cleveland Indians | TEIXEIRA, MARK (1B) [Protected] | 20625000 | Signed |
| 1 | 2 | Kansas City Royals | CABRERA, MIGUEL (1B) [Protected] | 14383049 | Signed |
| 1 | 3 | Houston Astros | REYES, JOSE (SS) [Protected] | 6125000 | Signed |
| 1 | 4 | Cincinnati Reds | WEBB, BRANDON (SP) [Protected] | 6500000 | Signed |
| 1 | 5 | Arizona Diamondbacks | PODSEDNIK, SCOTT (OF) [Protected] | 400000 | Signed |
| 1 | 6 | Texas Rangers | WILLIS, DONTRELLE (SP) [Protected] | 10000000 | Injured reserve |
| 1 | 7 | New York Yankees | BALDELLI, ROCCO (OF) [Protected] | 500000 | Signed |
| 1 | 8 | Texas Rangers | HARDEN, RICH (SP) [Protected] | 7000000 | Signed |
| 1 | 9 | | 2007 ROUND 5-12, DRAFTED (SP) [Unprotected] | 400000 | Waivers |
| 1 | 10 | San Diego Padres | GERUT, JODY (OF) [Unprotected] | 1775000 | Signed |
| 1 | 11 | Chicago Cubs | CROSBY, BOBBY (SS) [Protected] | 5300000 | Signed |
| 1 | 12 | San Francisco Giants | JACKSON, EDWIN (SP) [Protected] | 2200000 | Signed |
| 1 | 13 | New York Yankees | WEEKS, RICKIE (2B) [Protected] | 2450000 | Signed |
| 1 | 14 | San Francisco Giants | MATSUI, HIDEKI (OF) [Protected] | 13000000 | Signed |
| 1 | 15 | | PHILLIPS, JASON (C) [Unprotected] | 400000 | Free agent |
| 1 | 16 | | SEO, JAE (SP) [Unprotected] | 400000 | Free agent |
| 1 | 17 | Minnesota Twins | BONDERMAN, JEREMY (SP) [Protected] | 12500000 | Injured reserve |
| 1 | 18 | Houston Astros | RAMIREZ, HORACIO (RP) [Unprotected] | 1800000 | Signed |
| 1 | 19 | Seattle Mariners | CONTRERAS, JOSE (SP) [Protected] | 10000000 | Signed |
| 1 | 20 | | MAY, DARRELL (RP) [Unprotected] | 400000 | Free agent |
| 1 | 21 | Texas Rangers | GREENE, KHALIL (SS) [Unprotected] | 6500000 | Signed |
| 1 | 22 | | 2010 ROUND 4-4, DRAFTED (OF) [Unprotected] | 400000 | Waivers |
| 1 | 23 | Texas Rangers | BAY, JASON (OF) [Protected] | 7800000 | Signed |
| 1 | 24 | Seattle Mariners | MORNEAU, JUSTIN (1B) [Protected] | 11600000 | Signed |
| 1 | 25 | Tampa Bay Devil Rays | BLAKE, CASEY (3B) [Protected] | 5000000 | Signed |
| 1 | 26 | | TSAO, CHIN-HUI (RP) [Unprotected] | 400000 | Free agent |
| 1 | 27 | New York Mets | UTLEY, CHASE (2B) [Protected] | 11285714 | Signed |
| 1 | 28 | | 2005 ROUND 4-26, DRAFTED (RP) [Unprotected] | 400000 | Waivers |