| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | Cincinnati Reds | WRIGHT, DAVID (3B) [Protected] | 14250000 | Signed |
| 1 | 2 | Houston Astros | MAUER, JOE (C) [Protected] | 23000000 | Signed |
| 1 | 3 | Cleveland Indians | UPTON, B.J. (OF) [Protected] | 4825000 | Signed |
| 1 | 4 | Boston Red Sox | GREINKE, ZACK (SP) [Protected] | 13500000 | Signed |
| 1 | 5 | | 2008 ROUND 6-18, DRAFTED (3B) [Unprotected] | 414000 | Waivers |
| 1 | 6 | Baltimore Orioles | RIOS, ALEXIS (OF) [Protected] | 12500000 | Signed |
| 1 | 7 | Atlanta Braves | SIZEMORE, GRADY (OF) [Protected] | 7666666 | Signed |
| 1 | 8 | Seattle Mariners | KOTCHMAN, CASEY (1B) [Protected] | 414000 | Signed |
| 1 | 9 | Anaheim Angels | KAZMIR, SCOTT (SP) [Protected] | 12000000 | Injured reserve |
| 1 | 10 | Tampa Bay Devil Rays | SWISHER, NICK (OF) [Protected] | 9100000 | Signed |
| 1 | 11 | | CAPELLAN, JOSE (RP) [Unprotected] | 414000 | Free agent |
| 1 | 12 | New York Mets | CLOSSER, J.D. (C) [Unprotected] | 414000 | Signed |
| 1 | 13 | | 2007 ROUND 3-29, DRAFTED (SP) [Unprotected] | 414000 | Waivers |
| 1 | 14 | | REED, JEREMY (OF) [Unprotected] | 550000 | Waivers |
| 1 | 15 | | SLEDGE, TERRMEL (OF) [Unprotected] | 414000 | Free agent |
| 1 | 16 | | MATSUI, KAZUO (2B) [Protected] | 414000 | Free agent |
| 1 | 17 | Florida Marlins | FRANCIS, JEFF (SP) [Protected] | 2000000 | Signed |
| 1 | 18 | | CASTILLO, JOSE (3B) [Unprotected] | 414000 | Free agent |
| 1 | 19 | San Diego Padres | HOLLIDAY, MATT (OF) [Protected] | 16317774 | Signed |