| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | Baltimore Orioles | HERNANDEZ, FELIX (SP) [Protected] | 3800000 | Signed |
| 1 | 2 | Baltimore Orioles | FRANCOEUR, JEFF (OF) [Protected] | 3375000 | Signed |
| 1 | 3 | Atlanta Braves | HERMIDA, JEREMY (OF) [Protected] | 2250000 | Signed |
| 1 | 4 | New York Mets | CAIN, MATT (SP) [Protected] | 2900000 | Signed |
| 1 | 5 | San Diego Padres | FIELDER, PRINCE (1B) [Protected] | 7000000 | Signed |
| 1 | 6 | New York Yankees | ZIMMERMAN, RYAN (3B) [Protected] | 3325000 | Signed |
| 1 | 7 | Boston Red Sox | MARTE, ANDY (1B) [Protected] | 400000 | Signed |
| 1 | 8 | San Diego Padres | SANTANA, ERVIN (SP) [Protected] | 3800000 | Signed |
| 1 | 9 | Cleveland Indians | LIRIANO, FRANCISCO (SP) [Protected] | 430000 | Signed |
| 1 | 10 | Cleveland Indians | MCCANN, BRIAN (C) [Protected] | 3700000 | Signed |
| 1 | 11 | San Diego Padres | DUKE, ZACH (SP) [Protected] | 2200000 | Signed |
| 1 | 12 | Texas Rangers | VERLANDER, JUSTIN (SP) [Protected] | 3675000 | Signed |
| 1 | 13 | Tampa Bay Devil Rays | STREET, HUSTON (RP) [Protected] | 4500000 | Signed |
| 1 | 14 | Kansas City Royals | HARDY, J.J. (SS) [Protected] | 4650000 | Signed |
| 1 | 15 | Atlanta Braves | REYES, ANTHONY (SP) [Protected] | 414200 | Signed |
| 1 | 16 | | 2008 ROUND 5-8, DRAFTED (OF) [Unprotected] | 400000 | Waivers |
| 1 | 17 | San Diego Padres | ENCARNACION, EDWIN (3B) [Protected] | 2425000 | Signed |
| 1 | 18 | Florida Marlins | JACKSON, CONOR (1B) [Protected] | 3050000 | Signed |
| 1 | 19 | Seattle Mariners | MCCARTHY, BRANDON (SP) [Protected] | 650000 | Signed |