| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | New York Yankees | YOUNG, DELMON (OF) [Protected] | 5375000 | Signed |
| 1 | 2 | San Diego Padres | DREW, STEPHEN (SS) [Protected] | 4650000 | Signed |
| 1 | 3 | New York Mets | HAMELS, COLE (SP) [Protected] | 9500000 | Signed |
| 1 | 4 | Houston Astros | WEAVER, JERED (SP) [Protected] | 7365000 | Signed |
| 1 | 5 | Houston Astros | MARTIN, RUSSELL (C) [Protected] | 4000000 | Signed |
| 1 | 6 | Cincinnati Reds | QUENTIN, CARLOS (OF) [Protected] | 5050000 | Signed |
| 1 | 7 | | 2008 ROUND 4-2, DRAFTED (SP) [Unprotected] | 414000 | Waivers |
| 1 | 8 | San Francisco Giants | SANCHEZ, ANIBAL (SP) [Protected] | 3700000 | Signed |
| 1 | 9 | Houston Astros | TULOWITZKI, TROY (SS) [Protected] | 5500000 | Signed |
| 1 | 10 | Oakland Athletics | MARKAKIS, NICK (OF) [Protected] | 10600000 | Signed |
| 1 | 11 | Florida Marlins | GARZA, MATT (SP) [Protected] | 5950000 | Signed |
| 1 | 12 | Milwaukee Brewers | KENDRICK, HOWIE (2B) [Protected] | 3300000 | Signed |
| 1 | 13 | Kansas City Royals | ZUMAYA, JOEL (RP) [Protected] | 1400000 | Signed |
| 1 | 14 | Houston Astros | BARFIELD, JOSH (2B) [Unprotected] | 414000 | Signed |
| 1 | 15 | Kansas City Royals | UGGLA, DAN (2B) [Protected] | 9146942 | Signed |
| 1 | 16 | San Diego Padres | YOUNG, CHRIS-OF (OF) [Protected] | 5200000 | Signed |
| 1 | 17 | Houston Astros | KINSLER, IAN (2B) [Protected] | 6200000 | Signed |
| 1 | 18 | Tampa Bay Devil Rays | ETHIER, ANDRE (OF) [Protected] | 9500000 | Signed |
| 1 | 19 | Milwaukee Brewers | LONEY, JAMES (1B) [Protected] | 4875000 | Signed |
| 1 | 20 | New York Yankees | PELFREY, MICHAEL (SP) [Protected] | 3925000 | Signed |
| 1 | 21 | | 2010 ROUND 3-24, DRAFTED (3B) [Unprotected] | 414000 | Waivers |
| 1 | 22 | Pittsburgh Pirates | MILLEDGE, LASTINGS (OF) [Unprotected] | 500000 | Signed |
| 1 | 23 | Boston Red Sox | SAITO, TAKASHI (RP) [Protected] | 1750000 | Signed |
| 1 | 24 | Texas Rangers | KEMP, MATT (OF) [Protected] | 7100000 | Signed |
| 1 | 25 | | JOHJIMA, KENJI (C) [Unprotected] | 414000 | Free agent |