| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | New York Yankees | YOUNG, DELMON (OF) [Protected] | 1152000 | Signed |
| 1 | 2 | Baltimore Orioles | DREW, STEPHEN (SS) [Protected] | 1500000 | Signed |
| 1 | 3 | New York Mets | HAMELS, COLE (SP) [Protected] | 4350000 | Signed |
| 1 | 4 | Milwaukee Brewers | WEAVER, JERED (SP) [Protected] | 400000 | Signed |
| 1 | 5 | Pittsburgh Pirates | MARTIN, RUSSELL (C) [Protected] | 3900000 | Signed |
| 1 | 6 | Cleveland Indians | QUENTIN, CARLOS (OF) [Protected] | 550000 | Signed |
| 1 | 7 | | 2008 ROUND 4-2, DRAFTED (SP) [Unprotected] | 400000 | Waivers |
| 1 | 8 | San Francisco Giants | SANCHEZ, ANIBAL (SP) [Protected] | 400000 | Signed |
| 1 | 9 | Pittsburgh Pirates | TULOWITZKI, TROY (SS) [Protected] | 1000000 | Signed |
| 1 | 10 | Houston Astros | MARKAKIS, NICK (OF) [Protected] | 3350000 | Signed |
| 1 | 11 | Milwaukee Brewers | GARZA, MATT (SP) [Protected] | 433300 | Signed |
| 1 | 12 | Milwaukee Brewers | KENDRICK, HOWIE (2B) [Protected] | 465000 | Signed |
| 1 | 13 | Kansas City Royals | ZUMAYA, JOEL (RP) [Protected] | 735000 | Signed |
| 1 | 14 | Cincinnati Reds | BARFIELD, JOSH (2B) [Unprotected] | 416100 | Signed |
| 1 | 15 | Kansas City Royals | UGGLA, DAN (2B) [Protected] | 5350000 | Signed |
| 1 | 16 | Cincinnati Reds | YOUNG, CHRIS-OF (OF) [Protected] | 1950000 | Signed |
| 1 | 17 | Houston Astros | KINSLER, IAN (2B) [Protected] | 3200000 | Signed |
| 1 | 18 | Texas Rangers | ETHIER, ANDRE (OF) [Protected] | 3100000 | Signed |
| 1 | 19 | Milwaukee Brewers | LONEY, JAMES (1B) [Protected] | 465000 | Signed |
| 1 | 20 | Texas Rangers | PELFREY, MICHAEL (SP) [Protected] | 2237500 | Signed |
| 1 | 21 | | 2010 ROUND 3-24, DRAFTED (3B) [Unprotected] | 410000 | Waivers |
| 1 | 22 | St. Louis Cardinals | MILLEDGE, LASTINGS (OF) [Protected] | 452000 | Signed |
| 1 | 23 | Tampa Bay Devil Rays | SAITO, TAKASHI (RP) [Protected] | 1500000 | Signed |
| 1 | 24 | Texas Rangers | KEMP, MATT (OF) [Protected] | 467000 | Signed |
| 1 | 25 | Baltimore Orioles | JOHJIMA, KENJI (C) [Protected] | 7666666 | Signed |