| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | Minnesota Twins | BRAUN, RYAN (OF) [Protected] | 1032500 | Signed |
| 1 | 2 | Toronto Blue Jays | MATSUZAKA, DAISUKE (SP) [Protected] | 8333333 | Signed |
| 1 | 3 | Texas Rangers | GORDON, ALEX (3B) [Protected] | 457000 | Signed |
| 1 | 4 | Baltimore Orioles | LINCECUM, TIM (RP) [Protected] | 650000 | Signed |
| 1 | 5 | Texas Rangers | GALLARDO, YOVANI (SP) [Protected] | 414000 | Signed |
| 1 | 6 | New York Mets | UPTON, JUSTIN (OF) [Protected] | 412000 | Signed |
| 1 | 7 | Tampa Bay Devil Rays | PENCE, HUNTER (OF) [Protected] | 439000 | Signed |
| 1 | 8 | Minnesota Twins | SLOWEY, KEVIN (SP) [Protected] | 440000 | Signed |
| 1 | 9 | Cleveland Indians | HUGHES, PHILIP (SP) [Protected] | 1150000 | Signed |
| 1 | 10 | Oakland Athletics | ELLSBURY, JACOBY (OF) [Protected] | 449500 | Signed |
| 1 | 11 | Anaheim Angels | OWINGS, MICAH (SP) [Protected] | 420000 | Signed |
| 1 | 12 | Kansas City Royals | CHAMBERLAIN, JOBA (SP) [Protected] | 432575 | Signed |
| 1 | 13 | Texas Rangers | BUCHHOLZ, CLAY (SP) [Protected] | 400000 | Signed |
| 1 | 14 | Kansas City Royals | MAYBIN, CAMERON (OF) [Protected] | 400000 | Signed |
| 1 | 15 | Houston Astros | SALTALAMACCHIA, JARROD (C) [Protected] | 410890 | Signed |
| 1 | 16 | Houston Astros | HAMILTON, JOSH (OF) [Protected] | 555000 | Signed |
| 1 | 17 | Tampa Bay Devil Rays | ESCOBAR, YUNEL (SS) [Protected] | 425000 | Signed |
| 1 | 18 | Kansas City Royals | BAILEY, HOMER (SP) [Protected] | 400000 | Signed |
| 1 | 19 | Arizona Diamondbacks | GUTHRIE, JEREMY (SP) [Protected] | 650000 | Signed |
| 1 | 20 | Seattle Mariners | REYNOLDS, MARK (3B) [Protected] | 422500 | Signed |
| 1 | 21 | Boston Red Sox | VOTTO, JOEY (1B) [Protected] | 437500 | Signed |
| 1 | 22 | Texas Rangers | LAROCHE, ANDY (3B) [Protected] | 413500 | Signed |
| 1 | 23 | Houston Astros | BUTLER, BILLY (1B) [Protected] | 421000 | Signed |
| 1 | 24 | Atlanta Braves | MORALES, FRANKLIN (SP) [Protected] | 402000 | Signed |