| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | Minnesota Twins | BRAUN, RYAN (OF) [Protected] | 4287500 | Signed |
| 1 | 2 | Toronto Blue Jays | MATSUZAKA, DAISUKE (SP) [Unprotected] | 10333333 | Signed |
| 1 | 3 | Texas Rangers | GORDON, ALEX (OF) [Protected] | 1400000 | Signed |
| 1 | 4 | Baltimore Orioles | LINCECUM, TIM (RP) [Protected] | 14000000 | Signed |
| 1 | 5 | Texas Rangers | GALLARDO, YOVANI (SP) [Protected] | 3500000 | Signed |
| 1 | 6 | New York Mets | UPTON, JUSTIN (OF) [Protected] | 4458333 | Signed |
| 1 | 7 | St. Louis Cardinals | PENCE, HUNTER (OF) [Protected] | 6900000 | Signed |
| 1 | 8 | Minnesota Twins | SLOWEY, KEVIN (SP) [Protected] | 2700000 | Signed |
| 1 | 9 | Cleveland Indians | HUGHES, PHILIP (SP) [Protected] | 2700000 | Signed |
| 1 | 10 | Houston Astros | ELLSBURY, JACOBY (OF) [Protected] | 2400000 | Signed |
| 1 | 11 | Anaheim Angels | OWINGS, MICAH (RP) [Protected] | 414000 | Signed |
| 1 | 12 | Texas Rangers | CHAMBERLAIN, JOBA (SP) [Protected] | 1400000 | Signed |
| 1 | 13 | Texas Rangers | BUCHHOLZ, CLAY (SP) [Protected] | 555000 | Signed |
| 1 | 14 | Kansas City Royals | MAYBIN, CAMERON (OF) [Protected] | 429100 | Signed |
| 1 | 15 | Boston Red Sox | SALTALAMACCHIA, JARROD (C) [Protected] | 750000 | Signed |
| 1 | 16 | Houston Astros | HAMILTON, JOSH (OF) [Protected] | 8750000 | Signed |
| 1 | 17 | Texas Rangers | ESCOBAR, YUNEL (SS) [Protected] | 2900000 | Signed |
| 1 | 18 | Kansas City Royals | BAILEY, HOMER (SP) [Protected] | 441000 | Signed |
| 1 | 19 | Arizona Diamondbacks | GUTHRIE, JEREMY (SP) [Protected] | 5750000 | Signed |
| 1 | 20 | Seattle Mariners | REYNOLDS, MARK (3B) [Protected] | 5333333 | Signed |
| 1 | 21 | Pittsburgh Pirates | VOTTO, JOEY (1B) [Protected] | 7410655 | Signed |
| 1 | 22 | Texas Rangers | LAROCHE, ANDY (3B) [Unprotected] | 600000 | Signed |
| 1 | 23 | Houston Astros | BUTLER, BILLY (1B) [Protected] | 3500000 | Signed |
| 1 | 24 | Houston Astros | MORALES, FRANKLIN (RP) [Protected] | 424000 | Signed |