| Round |
DraftPick |
Team |
Pick/Player |
Salary |
Status |
| 1 | 1 | San Francisco Giants | LONGORIA, EVAN (3B) [Protected] | 550000 | Signed |
| 1 | 2 | Houston Astros | BRUCE, JAY (OF) [Protected] | 417500 | Signed |
| 1 | 3 | Houston Astros | PRICE, DAVID (SP) [Protected] | 400000 | Signed |
| 1 | 4 | Seattle Mariners | KERSHAW, CLAYTON (SP) [Protected] | 404000 | Signed |
| 1 | 5 | | 2010 ROUND 4-2, DRAFTED (SP) [Unprotected] | 435000 | Waivers |
| 1 | 6 | Baltimore Orioles | DAVIS, CHRIS (1B) [Protected] | 406620 | Signed |
| 1 | 7 | Pittsburgh Pirates | CUETO, JOHNNY (SP) [Protected] | 418000 | Signed |
| 1 | 8 | Milwaukee Brewers | FOWLER, DEXTER (OF) [Protected] | 401000 | Signed |
| 1 | 9 | Oakland Athletics | SCHERZER, MAX (SP) [Protected] | 1450000 | Signed |
| 1 | 10 | Atlanta Braves | RAMIREZ, ALEXEI (2B) [Protected] | 1225000 | Signed |
| 1 | 11 | Boston Red Sox | VOLSTAD, CHRIS (SP) [Protected] | 400000 | Signed |
| 1 | 12 | Cincinnati Reds | KURODA, HIROKI (SP) [Protected] | 12433333 | Signed |
| 1 | 13 | Cleveland Indians | SNIDER, TRAVIS (OF) [Protected] | 401400 | Signed |
| 1 | 14 | Cleveland Indians | LOWRIE, JED (SS) [Protected] | 414000 | Signed |
| 1 | 15 | Milwaukee Brewers | SPAN, DENARD (OF) [Protected] | 435000 | Signed |
| 1 | 16 | Minnesota Twins | SANDOVAL, PABLO (3B) [Protected] | 401750 | Signed |
| 1 | 17 | Milwaukee Brewers | MASTERSON, JUSTIN (SP) [Protected] | 415500 | Signed |
| 1 | 18 | Atlanta Braves | AVILES, MIKE (SS) [Protected] | 424500 | Signed |
| 1 | 19 | Toronto Blue Jays | ESCOBAR, ALCIDES (SS) [Protected] | 400000 | Signed |
| 1 | 20 | New York Mets | GAMEL, MAT (3B) [Protected] | 400000 | Signed |
| 1 | 21 | Atlanta Braves | ARREDONDO, JOSE (RP) [Unprotected] | 410000 | Signed |
| 1 | 22 | Anaheim Angels | CAMPILLO, JORGE (SP) [Protected] | 420000 | Signed |
| 1 | 23 | Tampa Bay Devil Rays | TEAGARDEN, TAYLOR (C) [Protected] | 401000 | Signed |
| 1 | 24 | Toronto Blue Jays | GONZALEZ, CARLOS (OF) [Protected] | 400000 | Signed |
| 1 | 25 | San Diego Padres | MORTON, CHARLIE (SP) [Protected] | 405000 | Signed |